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Home » Improving Neuropathy With Functional Medicine and Genetics

October 7, 2018 by Dr. Michael Veselak, D.C. Leave a Comment

Improving Neuropathy With Functional Medicine and Genetics

The current approach for the treatment of neuropathy has not been very successful. There are millions of people that suffer with this condition all across this country. There are several reasons for this failure in part because there are so many causes of neuropathy and in part because the treatment is not directed towards the whole body. The field of medicine addresses symptoms, diagnosing the problem and then prescribing a medication that hopefully will suppress the symptoms.

The cause is rarely found or for that matter rarely searched for. Sure the diabetic or chemo induced neuropathy are relatively easy to diagnose. What is required is a whole body approach. A cure for neuropathy will never be found if we continue with our current approach.

Whole Body Approach

A whole body approach for example for the diabetic neuropathy would be to prescribe dietary guidelines to normalize the HbA1c or the blood sugar levels. Exercise would be prescribed to improve the insulin sensitivity. Supplementation would be recommended to assist in the reduction of inflammation, repairing of the cell and nerves, improve digestion and assimilation, detoxification and elimination.

This approach would be slightly different and personalized for that individual dependent upon their causes, lab markers and of course their genetics.

Genetics is proving to be a game changer when working with chronic patients. It allows us to interpret potential vulnerabilities in methylation, (the utilization of B vitamins and Folate), detoxification, ability to handle chemical toxicity or pesticides, production of choline a necessary component in the myelin, and the body’s ability to produce glutathione the major antioxidant.

The Root Causes

When I evaluate the root causes of all chronic issues including neuropathy I always look at these 6 factors: Inflammation, Methylation, Mitochondrial Health, Detoxification, Genetics and Autophagy.

  1. Inflammation:  When our immune system is more over active producing more cytokines and inflammatory markers. There are a lot of reasons for this including the toxic environment we live in and the exposure of an enormous amount of chemicals, molds, and heavy metals.  The processed foods we eat are loaded with preservatives, chemicals creating a very unhealthy environment in our gut and adversely affecting our ability to digest, absorb and assimilate our food.

  2. Methylation:  This is our ability to convert green leafy vegetables into a useable form of folate and combine and manufacture enough B12 to allow us to detoxify, make neurotransmitters and produce anti-oxidants.  Genetic markers for this are the MTHR, MTRR, MTHFD, MTR, COMT, NDUF as well as several others.

  3. Mitochondrial Health:  The mitochondria are the battery of the cell. It provides energy in the form of ATP.  If there is not enough energy production the body will have difficulty performing its necessary functions and fatigue or lack of endurance will set in.   This creates another set of problems within the cell with regards to the sodium and potassium pump and the exchange of key minerals.  Ultimately, this affects the frequency of firing of the nerve and the slightest impulse can cause this nerve to be activated.

  4. Detoxification:  It is important to address the ability to detoxify properly in the liver and its ability to convert these toxins to a water-soluble form.  The interaction with digestive enzymes and bile is also important when looking at detoxification.  Glutathione is our body’s major antioxidant and if we can see vulnerabilities in our ability to produce glutathione and help with the removal of chemicals and heavy metals.  The PON1 gene is extremely common snp that I clinically see in practice.  The function is the removal of pesticides in the body.   Also, the CYP1 and CYP2 genes need to be closely looked at. This is our cytochrome P450 system, which helps with the conjugation of the toxins and the conversion to the water-soluble form.

  5. Genetics:  The role of genetics has to be taken into consideration. The specific vulnerabilities each of us has and the expression of these genes.  There are several important genes to consider.  MTHFR C677t and A1298c and its effects on methylation and the ability to produce neurotransmitter.  The CYP1 and CYP2 genes and detoxification.   We want to take a close look at the NDUF genes and its impact on the mitochondria.  NOS, SOD and GSTM1 for oxidative stress and glutathione production.  The goal is to assess the individual for potential vulnerabilities and support the body to minimize of eliminate the expression of those genes.

  6. Autophagy:  This is the ability of cell to clean itself from the debris.  In other words if the trash keeps building up how can the cell or for that matter the mitochondria function properly.    The discovery of this process was recent and was so significant that it won the medical Nobel Prize.  It has been linked to several of the chronic degenerative diseases such as Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease.

Diet and Lifestyle Changes

With all chronic disease including Peripheral Neuropathy these six areas must be addressed along with diet and lifestyle changes.

Sleep
Exercise
Anti-inflammatory or Nutrient Dense Food Program
Meditation
Eliminate or Reduce Exposure to Toxins

Treatment

Treatments and therapies are much more effective when they are personalized to that individuals particular problem. Is it methylation, mitochondrial dysfunction?

When the mitochondria are affected, remember this is the battery; the energy of the cell, the first place it will affect is the brain and nervous system. It is our most energy dependent system in the body. The second place it will affect is the immune system and then finally the muscular system.

Dependent on what genetic snps we have there are certain supplements that help to restore mitochondrial health. It could be NADH, D-ribose, COQ10, Ubiquinol, Magnesium, Carnitine or Alpha Lipoic Acid.

The solution is slightly different for everyone and there is no one size fits all. We have to determine which of these or a combination of these 6 factors are affected and provide support nutritionally along with the lifestyle factors mentioned above. I strongly believe that with the right approach a cure could be found for those that suffer with Peripheral Neuropathy.

Therapies

In the office we utilize several techniques to help to activate and regenerate the nerves.  Microcurrent like the Hako-Med has proven to be an effective tool.  Cold Laser and Infrared therapy to help restore mitochondrial function and promote circulation is also utilized.

Exercises designed to activate the small nerve fibers for proprioception, balance, vibration and pain perception are utilized.

Dr. Michael Veselak’s Book on Neuropathy

As outlined in his best selling book on Amazon “Understanding, Managing and Improving Your Neuropathy,” a whole body approach is necessary to make changes to the patient that suffers from neuropathy.  Proper Testing is also necessary to determine the cause. Remember it is different for everyone.

 

Filed Under: Chronic Pain, Functional Medicine, Genetics, Neuropathy Tagged With: burning pain, Chronic Pain, diabetic neuropathy, functional medicine, Genetics, methylation, mitochondria, Numbness, peripheral neuropathy, tingling

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Dr. Michael Veselak and his spinal decompression clinic have changed my life in a way I never would have thought possible. Now, five weeks after I started my treatment, I’m back to my very active lifestyle. During my entire treatment, I’ve been completely medication free. I couldn’t have done it without Dr. Veselak. I would highly recommend this treatment to anyone faced with surgery as their only option or people that have chronic neck and/or back pain. This is an option you cannot afford to pa… Read more
Umrao M.
Dr. Veselak is a gifted healer, compassionate doctor and wonderful human being. I am so blessed to have been referred to him by my good friend Marylin. After dealing with several issues for so many years Dr V. was able to get to the root of my problems. I was starting to think I was crazy because every test, scan and ultra sound came back negative. I went to various doctors and they all just assumed I was dealing with a thyroid issue. I’m so grateful that instead of assuming or guessing I fou… Read more
Erica D
Okay, Dr. Veselak has literally changed my health for the better to say the least!! I had stomach issues  that had lasted over two years and I had gone to  a few regular medical doctors on my insurance. No one could help, and honestly I don’t think they really cared. Dr. Veselak‘s treatment program is all natural and it is formulated to be exactly what your body is in need of. It’s based on your  own personal DNA, so he dials in on what is going on in your body. Not a guessing game, or a on… Read more
Anita P.

About Dr. Michael Veselak, D.C.

Dr. Michael Veselak, D.C. has been practicing Chiropractic care in Camarillo, California for over 33 years. Throughout his experience, Dr. Veselak has recognized the importance of treating each patient based on their condition rather than their symptoms. In recent years, Dr. Michael Veselak has become a Certified Functional Medicine Practitioner and Board Certified in Integrative Medicine, allowing him to evaluate each patient neurologically and metabolically, as well as from a chiropractic standpoint. In doing so, Dr. Veselak has seen tremendous success in his patients suffering from chronic conditions such as Peripheral Neuropathy, Chronic Pain, Fibromyalgia, Spinal Stenosis, Degenerative Disc Problems, and Thyroid Disorders.

Using state-of-the-art technology, such a Cold Laser, Hako-Med, Spinal Decompression, Vibration Therapy and Brain-based exercises, Dr. Michael Veselak has witnessed profound effects with various chronic conditions. It is his mission to leave no stone unturned in getting to the root cause of your pain, rather than merely treating the symptoms with medications.

If you or someone you know is suffering from a chronic condition, please contact Dr. Michael Veselak at (805) 482-0723.

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"Dr. Michael Veselak and his spinal decompression clinic have changed my life in a way I never would have thought possible. Now, five weeks after I started my treatment, I'm back to my very active lifestyle. During my entire treatment, I've been completely medication free. I couldn't have done it without Dr. Veselak. I would highly recommend this treatment to anyone faced with surgery as their only option or people that have chronic neck and/or back pain. This is an option you cannot afford to pass up." - Umrao M.

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