Research confirms that the root cause for many undesired immune reactions originates in the gastrointestinal tract. GI tract abnormality can compromise the integrity of the gut barrier and increases the entry of undigested antigens into the sub-mucosa and the circulation, thus challenging the immune system. Reaction to these antigens activates immune and inflammatory cascades, resulting in the production of pro-inflammatory cytokines and an array of antibodies, which further contributes to increased intestinal barrier permeability (or “leaky gut” syndrome).

Cyrex offers tests measuring predictive antibodies to a variety of key antigens. These antigens are arranged into groups, called Arrays, which are specifically designed for clinical applications. We use Array 2, 3, 4, and 10 to test for intestinal permeability, food sensitivities, and food immune reactivity.

Array 2 measures intestinal permeability to large molecules which inflame the immune system and identifies the damaging route through the intestinal barrier. This test is recommended for patients who present multiple symptom complaints (including Chronic Fatigue Syndrome), who suffer from abnormal immune cell count and function (including autoimmune diseases), or patients who complain of food allergy and intolerance.

Array 3 accurately identifies Gluten Reactivity and measures antibody production against nine wheat proteins and peptides and three structure enzymes. This test is recommended for patients who have non-responsive GI symptoms, present multiple-symptom complaints (including Chronic Fatigue Syndrome and Fibromyalgia), or suffer from depression or neuro-autoimmunity.

Array 4 identifies additional dietary proteins to which the Non-Celiac Gluten Sensitive (NCGS) or Celiac Disease (CD) patient is sensitized; detects cross-reactions in the patient non-responsive on a gluten-free diet; and categorizes the 1-in-2 NCGS or CD patient who is also sensitive to dairy products. This test is recommended for patients who have Non-Celiac Gluten Sensitivity or Celiac Disease, are experiencing limited improvements or are non-responsive on a gluten-free diet, or have gut dysbiosis, which appears to be resistant to standard therapy.

Array 10 evaluates immune reactions to foods, raw and/or modified, food enzymes, lectins and food additives, including meat glue, artificial colorings and gums; early detection of dietary-related triggers of autoimmune reactivity; monitors the effectiveness of customized dietary protocol in the patient. This test is recommended for patients who seek a life-long health and wellness strategy, present with unexplained symptoms whether gastrointestinal, neurological, dermatological or behavioral in nature, or are having increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders.