The cause is rarely found or for that matter rarely searched for. Sure the diabetic or chemo induced neuropathy are relatively easy to diagnose. What is required is a whole body approach. A cure for neuropathy will never be found if we continue with our current approach.

Whole Body Approach

A whole body approach for example for the diabetic neuropathy would be to prescribe dietary guidelines to normalize the HbA1c or the blood sugar levels. Exercise would be prescribed to improve the insulin sensitivity. Supplementation would be recommended to assist in the reduction of inflammation, repairing of the cell and nerves, improve digestion and assimilation, detoxification and elimination.

This approach would be slightly different and personalized for that individual dependent upon their causes, lab markers and of course their genetics.

Genetics is proving to be a game changer when working with chronic patients. It allows us to interpret potential vulnerabilities in methylation, (the utilization of B vitamins and Folate), detoxification, ability to handle chemical toxicity or pesticides, production of choline a necessary component in the myelin, and the body’s ability to produce glutathione the major antioxidant.

The Root Causes

When I evaluate the root causes of all chronic issues including neuropathy I always look at these 6 factors: Inflammation, Methylation, Mitochondrial Health, Detoxification, Genetics and Autophagy.

1. Inflammation:  When our immune system is more over active producing more cytokines and inflammatory markers. There are a lot of reasons for this including the toxic environment we live in and the exposure of an enormous amount of chemicals, molds, and heavy metals.  The processed foods we eat are loaded with preservatives, chemicals creating a very unhealthy environment in our gut and adversely affecting our ability to digest, absorb and assimilate our food.

2. Methylation:  This is our ability to convert green leafy vegetables into a useable form of folate and combine and manufacture enough B12 to allow us to detoxify, make neurotransmitters and produce anti-oxidants.  Genetic markers for this are the MTHR, MTRR, MTHFD, MTR, COMT, NDUF as well as several others.

3. Mitochondrial Health:  The mitochondria are the battery of the cell. It provides energy in the form of ATP.  If there is not enough energy production the body will have difficulty performing its necessary functions and fatigue or lack of endurance will set in.   This creates another set of problems within the cell with regards to the sodium and potassium pump and the exchange of key minerals.  Ultimately, this affects the frequency of firing of the nerve and the slightest impulse can cause this nerve to be activated.

4. Detoxification:  It is important to address the ability to detoxify properly in the liver and its ability to convert these toxins to a water-soluble form.  The interaction with digestive enzymes and bile is also important when looking at detoxification.  Glutathione is our body’s major antioxidant and if we can see vulnerabilities in our ability to produce glutathione and help with the removal of chemicals and heavy metals.  The PON1 gene is extremely common snp that I clinically see in practice.  The function is the removal of pesticides in the body.   Also, the CYP1 and CYP2 genes need to be closely looked at. This is our cytochrome P450 system, which helps with the conjugation of the toxins and the conversion to the water-soluble form.

5. Genetics:  The role of genetics has to be taken into consideration. The specific vulnerabilities each of us has and the expression of these genes.  There are several important genes to consider.  MTHFR C677t and A1298c and its effects on methylation and the ability to produce neurotransmitter.  The CYP1 and CYP2 genes and detoxification.   We want to take a close look at the NDUF genes and its impact on the mitochondria.  NOS, SOD and GSTM1 for oxidative stress and glutathione production.  The goal is to assess the individual for potential vulnerabilities and support the body to minimize of eliminate the expression of those genes.

6. Autophagy:  This is the ability of cell to clean itself from the debris.  In other words if the trash keeps building up how can the cell or for that matter the mitochondria function properly.    The discovery of this process was recent and was so significant that it won the medical Nobel Prize.  It has been linked to several of the chronic degenerative diseases such as Alzheimer’s, Parkinson’s, and Lou Gehrig’s disease.

Diet and Lifestyle Changes

With all chronic disease including Peripheral Neuropathy these six areas must be addressed along with diet and lifestyle changes.

Sleep
Exercise
Anti-inflammatory or Nutrient Dense Food Program
Meditation
Eliminate or Reduce Exposure to Toxins

Treatment

Treatments and therapies are much more effective when they are personalized to that individuals particular problem. Is it methylation, mitochondrial dysfunction?

When the mitochondria are affected, remember this is the battery; the energy of the cell, the first place it will affect is the brain and nervous system. It is our most energy dependent system in the body. The second place it will affect is the immune system and then finally the muscular system.

Dependent on what genetic snps we have there are certain supplements that help to restore mitochondrial health. It could be NADH, D-ribose, COQ10, Ubiquinol, Magnesium, Carnitine or Alpha Lipoic Acid.

The solution is slightly different for everyone and there is no one size fits all. We have to determine which of these or a combination of these 6 factors are affected and provide support nutritionally along with the lifestyle factors mentioned above. I strongly believe that with the right approach a cure could be found for those that suffer with Peripheral Neuropathy.

Therapies

In the office we utilize several techniques to help to activate and regenerate the nerves.  Microcurrent like the Hako-Med has proven to be an effective tool.  Cold Laser and Infrared therapy to help restore mitochondrial function and promote circulation is also utilized.

Exercises designed to activate the small nerve fibers for proprioception, balance, vibration and pain perception are utilized.

Dr. Michael Veselak’s Book on Neuropathy

As outlined in his best selling book on Amazon “Understanding, Managing and Improving Your Neuropathy,” a whole body approach is necessary to make changes to the patient that suffers from neuropathy.  Proper Testing is also necessary to determine the cause. Remember it is different for everyone.

The post Improving Neuropathy With Functional Medicine and Genetics appeared first on Dr. Michael Veselak, D.C., CFMP.

Generally medications are given that increase insulin levels which does not really affect the ability to bring glucose into the cells. The body has several ways too remove this excess glucose basically by bringing it back in the liver and turning it into triglycerides or fat. Through time this will affect many of the organs including the kidneys, heart, eyes and can create a lot of serious issues including Peripheral Neuropathy.

What Can We Do To Reduce Blood Glucose?
The most important and obvious factor is we must reduce the amount of sugar we consume. We have to reduce simple carbohydrates, read labels and eliminate high sugar content in foods and drinks, and reduce the levels of fructose.
Fructose is a big part of the problem. Fructose cannot be utilized by the whole body and gets stored in the liver and contributes to high triglycerides and non-alcoholic fatty liver disease. The pancreas as well will get affected by this high fat content and will have more difficulty secreting insulin.

Where Does All This Fructose Come From?
Fructose is the sugar source we receive from fruits but this is not altogether the problem. The biggest issue is the amount of high fructose corn syrup that is added to a lot of our foods. This is an inexpensive additive that is placed in processed foods, energy drinks and soft drinks.

Fatty Liver Disease More Common In Adults and Children
As a result of our poor dietary habits and the shifting from whole foods to processed and fast foods there has been a dramatic increase in fatty liver disease in children as well as adults.

What Can We Do?
When we see the real problem is the consumption of too much fructose we need to control our dietary intake. Fructose from processed foods, soft drinks and energy drinks needs to be eliminated completely.

Then to jump-start the body to it helps to begin to consume less food. We recommend intermittent fasting, which is following dinner try not to eat for a period of 18 hours. For example if your last meal were at 6pm then your next meal would be at noon the following day.

We also recommend eating 3 meals per day, if possible, rather than grazing all day long like we were taught.

The foods we eat also matters of course. We endorse a ketogenic type diet where the emphasis is placed on fat, good fat. Our brain and nerves love fat. When our diet is consumed mostly by fat then we tend to burn ketones as a major source of energy instead of glucose. There is a lot of research suggesting Ketogenic diet is beneficial for chronic degenerative conditions such as Diabetes and Peripheral Neuropathy.

Effects on Pancreas and Liver
When our body becomes a fat burning machine the first place it burns fat is the pancreas and liver. This will help with the body’s natural ability to secrete insulin and help remove the excess blood sugar in the body. Over time people have become less reliant on their medication as their HbA1c becomes within normal ranges.

Action Steps:

• Stop Eating Processed Foods, Energy Drinks

• Check Fructose Corn Syrup On Food Labels and Avoid

• Begin Eating Whole Foods

• Implement Intermittent Fasting

• Begin Ketogenic Diet and Eat More Healthy Fat

• Proper Supplementation To Support Healthy Glucose Metabolism

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